Benzodiazepines & Neuropsychiatric ICU Outcomes

Benzodiazepines are increasingly falling out of favour as sedation agents in ICU because of their association with delirium in particular. Dexmedetomidine on the other hand is finding favour because of better outcomes in that regard.

This systematic review concludes: “The majority of included studies indicated that benzodiazepine use in the ICU is associated with delirium, symptoms of posttraumatic stress disorder, anxiety, depression, and cognitive dysfunction. Future well-designed studies and randomized controlled trials are necessary to rule out confounding by indication”.

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