Intranasal Ketamine for Extremity Injuries in Children

A small non-inferiority study on children aged 8- 17 with extremity injuries (mostly fractures) compared intranasal Ketamine 1.5 mg/kg with Fentanyl 2 mcg/kg.

Ketamine produced effective analgesia that was non-inferior to Fentanyl, but did have more what are characterized as minor side effects, eg. dizziness or somnolence; these were short-lived. No serious adverse events, such as respiratory or hemodynamic, occurred.

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