This POPPI trial involved a multifaceted intervention that included promotion of a therapeutic environment by ICU staff and targeted stress support sessions delivered by trained ICU nurses to ICU patients who demonstrated acute stress symptom.
Overall, there was no significant difference in the primary outcome of PTSD symptom severity.
Neither was there any significant differences in secondary outcomes, including days alive and free from sedation at day 30, length of ICU stay, symptoms of depression and anxiety, and health-related quality of life.
Future targeting may involve better selection of at-risk populations, timing, frequency, specific techniques, staff training, and implementation issues. Amelioration of agitation and delirium may also be worthwhile endeavours.