Traumatic Brain Injury and Goal Directed Therapy

“The Progesterone for the Treatment of Traumatic Brain Injury III clinical trial rigorously monitored compliance with goal-directed therapy after traumatic brain injury. Multiple significant associations between physiologic transgressions, morbidity, and mortality were observed. These data suggest that effective goal-directed therapy in traumatic brain injury may provide an opportunity to improve patient outcomes”

This was a planned secondary analysis and the physiologic transgressions referenced include deviations like anemia (Hb <8), hyperglycaemia, low mean (< 65) or systolic blood pressure, raised INR > 1.4, and raised ICP > 20

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