Another meta-analysis reflecting ongoing interest in inhalational vs. total intravenous anesthesia (TIVA) and cancer outcomes.
The use of TIVA was associated with improved recurrence-free as well as overall survival in all cancer types. It was especially evident where major cancer surgery was undertaken. Breast surgery was studied most extensively.
Most studies were retrospective, with varying follow-up, demographic variations, population imbalance, cancer grade/stage differences, different surgery magnitude, and other anesthetic technique differences. It is therefore necessary to be cautious about the findings and wait for larger randomized studies to confirm what could be a major finding in favour of Propofol-based TIVA.