Many agents have been added to peripheral nerve blocks to prolong analgesia. In some cases intravenous administration has been as successful without potential nerve toxicity concerns.
This small randomized study evaluated the difference in time to first rescue analgesic request between patients receiving co-administered intravenous dexamethasone and dexmedetomidine and patients receiving intravenous dexamethasone alone after single-shot interscslene brachial plexus block for arthroscopic shoulder surgery. Saline controls were used.
Co-administration of intravenous dexamethasone (0.11 mg kg−1) with dexmedetomidine (1.0 μg kg−1) significantly prolonged the time to first rescue analgesic request more than Dexamethasone alone, and both more so than saline controls. Also both groups had reduced postoperative opioid consumption, less sleep disruption and improved patient satisfaction compared with the control group.