Blood Purification and Mortality in Sepsis and Septic Shock

A systemic review and meta-analysis of a variety of modalities such as hemoperfusion, hemofiltration without a renal replacement purpose, and plasmapheresis as a blood purification technique were compared to conventional therapy in adult patients with sepsis and septic shock.

“Very low-quality randomized evidence demonstrates that the use of hemoperfusion, hemofiltration, or plasmapheresis may reduce mortality in sepsis or septic shock.”

Clearly the evidence for these “blood purification” strategies will require further randomized higher quality trials before they can be routinely recommended.


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