A post-how analysis of a previous trial compares Preoxygenation strategies for critically ill patients to minimize hypoxia. They compared bag/mask, non-rebreather, non-invasive ventilation, and high flow nasal oxygenation.
While they found that the main determinants of hypoxemia during endotracheal intubation may be related to critical illness severity and to preexisting hypoxemia, the best performer was non-invasive ventilation.
Post hoc analyses are maligned as “data dredging” that are not designed for these secondary results, but they can also extract useful data. This implies further randomized studies should be done to confirm these findings.