A population study in Sweden raises concerns regarding the widespread use of gabapentinoids for pain, sometimes with poor evidence bases, and in an effort to curb opioid overuse. However they bring issues of their own in terms of adverse effects, drug interaction and even misuse (search this blog!).
“This study suggests that gabapentinoids are associated with an increased risk of suicidal behaviour, unintentional overdoses, head/body injuries, and road traffic incidents and offences. Pregabalin was associated with higher hazards of these outcomes than gabapentin.”
“When stratifying on age, increased hazards of all outcomes were associated with participants aged 15 to 24 years.”