Hot on the heels of the pediatric study below ( link ) yet another linking of so-called normal saline to worse outcomes
“Among critically ill adults, the use of balanced crystalloids for intravenous fluid administration resulted in a lower rate of the composite outcome of death from any cause, new renal-replacement therapy, or persistent renal dysfunction than the use of saline”. The % differences were not huge
An excellent accompanying editorial, while finding the trial informative, also cautions the use of composite vs. patient-centred outcomes.
And in non-critically ill, another perspective – no mortality benefit but still a renal benefit link